The principle of mutual advantage securing the opportunity for the parties of economic cooperation to accrue benefits on equal and non-discriminatory basis and enshrined in several multilateral international documents is considered to be one of the most important principles of the international economic law.The article, including six paragraphs besides the introduction and the conclusion deals with the different aspect of the USA activity on the international scene disregarding this principle and leading to unilateral advantages and benefits.The first paragraph focuses on abusive actions taken on the national level leading to the creation of obstacles and disadvantageous economic conditions for the US partners. The second paragraph describes international economic agreements concluded by Russia on the unequal terms of the USA. Jackson-Vanik amendment removing the most favorite nation clause in the economic cooperation of Russia and the USA is the subject of the third paragraph. The forth paragraph deals with the extraterritorial laws of the USA attempting to restrict the sovereignty and the economic independence of other states. The fifths and the sixth paragraphs are devoted to the country classifications helping to justify the subsequent discriminative actions and economic sanctions against these countries aimed at irreciprocal advantage of the USA.In conclusion the author offers some actions to be taken at the international level in order to leave the practice of receiving unilateral benefits, secure the fulfillment of the principle of mutual advantage and guarantee the equal economic cooperation.The article contains examples of the international agreements and of the national laws of the USA.